PSYCH 4Y03 Lecture Notes - Lecture 10: Congenital Adrenal Hyperplasia, X Chromosome, Sexual Dimorphism
8 Apr 2017
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Reproductive role, strategy: females more nurturing than males, males cannot lactate. Verbal maturation: earlier in girls than boys on average. Male hpg axis differs from female hpg axis. Gonadotropin activity: acyclical vs cyclical: female system produces gnrh cyclically, acyclical in males. Activin + inhibin dynamics modulate gnrh production. Bi-potentiality in gene expression and gonads default is female: the gonads contain both tracts initially (during first trimester) The determining factor is the on the short arm of y chromosome contains critical info. (sry): when this gene is expressed in primordial gonads, a protein (tdf) causes male differentiation of fetal gonads. Embryonic testes: testosterone (t) stimulates wolffian (male) duct growth and: mih causes regression of m llerian duct (the female reproductive tract). The absence of testosterone causes m llerian duct growth. Dihydrotestosterone (dht), produced in testes, prostate, and adrenals as metabolite of t, stimulates fusing of external genitalia and other male characteristics.
