PHYS30001 Lecture Notes - Lecture 26: Cardiovascular Disease, Mammary Gland, Wky
Document Summary
Reduces fetal nutrition, leading to growth restriction mimics features of human intrauterine growth restriction in western society. Surgery on day 18 of gestation in wky rats (term = 22 days): ligation of uterine artery/veins severely reduces blood supply. Offspring born small (~10% decrease in birth weight) Reduced milk quality and quantity during lactation impaired lactational nutrition compromises postnatal growth with consequences for adult disease development. Females don"t develop hypertension even by 18 months. Intervention studies - nutrition and accelerated postnatal growth. 90% of small babies have some accelerated growth in first 6 months. Accelerated growth independently associated with increased risk of adult diseases. Late accelerated growth (after 1st year) is detrimental. Cross-fostering at birth to define critical periods of development & programming of increased blood pressure and disease. Letters depict significances between group, a is the lowest. Cross-fostering restricted males onto control mothers improves postnatal body weight due to early accelerated growth.
