PHYS30001 Lecture Notes - Lecture 26: Coronary Artery Disease, Cardiovascular Disease, Birth Weight
Document Summary
Heart - adults who were born small are susceptible to: Standardised mortality ratios for cardiovascular disease below the age of 65 by sex and birth weight in hertfordshire. Individuals born small have higher mortality rates of cardiovascular disease compared to normal birth weight individuals. Non-fatal coronary heart disease and stroke according to birthweight: american nurses study (1997) Individuals born small are at a greater risk of non-fatal coronary heart disease and stroke compared to normal birth weight individuals. Link between early bmi, height & weight and later coronary heart disease. Increased weight and bmi gain during adolescence, associated with increased risk of. Brain - hpa axis: adults who were born small are susceptible to: Altered mineralo and glucocorticoid receptors: enhanced response due to more receptors. Greater hypothalamic pituitary adrenal axis responsiveness to "stress" Vasculature: adults who were born small are susceptible to: Altered vascular / endothelial reactivity to vasoconstrictors and vasodilators - reduced responsiveness.
