NEUR30004 Lecture Notes - Lecture 12: Nav1.8, Neve Electronics, Ibuprofen

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Pain 1 - peripheral mechanisms: initiation of pain: Pain is an unpleasant sensory or emotional experience associated with actual or potential tissue damage (or it is described in terms of damage). * pain is a major problem and it is the primary reason that people seek medical assistance in the western world. If it is acute pain it could be well treated but when pain becomes chronic, it becomes a real problem. * if (cid:455)ou do(cid:374)(cid:859)t ha(cid:448)e se(cid:374)siti(cid:448)it(cid:455) to pai(cid:374) the(cid:374) the(cid:396)e is a (cid:373)ajo(cid:396) p(cid:396)o(cid:271)le(cid:373) e. g. people (cid:272)a(cid:374) do (cid:374)ot take (cid:272)a(cid:396)e to prevent tissue damage, prone to burning themselves. * so, pain is a protective mechanisms because it brings awareness of damage occurring or about to happen. * sensory-discriminative aspects: location, intensity, duration of the pain. * motivational-affective dimensions: unpleasant feelings (e. g. anxiety, distress, fear and depression), associated with pain.

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