BIOL30001 Lecture Notes - Lecture 26: Embryonic Stem Cell, Mesenchymal Stem Cell, Adult Stem Cell
16 Oct 2018
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Document Summary
Totipotent = fertilized oocyte and cells after rst cleavage divisions; ability to form entire organism. Pluripotent = cells of the inner cell mass of the blastocyst; ability to form all three germ layers, but not the extra-embryonic tissue) embryonic stem cells. Multipotent = mesenchymal stem cells which can form bone, cartilage and fat; ability to form multiple cell types adult stem cells. Day 4 = compaction = rst major decision event (inside/outside) Blastocyst stage is when we rst see di erentiation. Implantation + signalling events = icm di erentiates into three germ layers. Germ layers = mesoderm muscle, endoderm endocrine, ectoderm brain and skin. Note: can"t really show in humans, so don"t truly know for sure if we have pluripotent stem cell populations. Commitment (cell autonomous) received signal and is acting on it epigenetic; transcription factor network. Patterning (environmental) looking to see where it is in space relative to other cells and the environment.
