BCCB2003 Lecture 3: Principles of Biochemistry BCCB2003 NOTES WEEK 3

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1 Aug 2018
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Ligand binding: a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose, the functions of many proteins is to reversibly bind to other molecules, this is a specific interaction: The protein structure is complimentary to the ligand: binding to a ligand usually leads to a change in protein conformation, this is called an induced fit, occurs in multi-subunit proteins. Myoglobin and haemoglobin contain lots of -helices: approximately 75% of all the amino acids in myoglobin and haemoglobin are present in an. Makes up about 34% of their weight. Stabilised by weak interactions: hydrophobic, hydrogen bonds. Ionic: oxygen is transported by haemoglobin in erythrocytes, erythrocytes are formed from haemocytoblasts (precursor stem cells) Forms daughter cells that synthesise lots of haemoglobin then lose their: haemoglobin can be found at approximately 34% of red blood cells weight by weight organelles (w/w) Approximately 96% saturated with oxygen when leaving the lungs.

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