BCCB2003 Lecture Notes - Lecture 8: Fructose-Bisphosphate Aldolase, Triosephosphate Isomerase, Ketone
Document Summary
Metabolic pathways: most reactions in cells are catalysed by enzymes, usually organised in a sequence of consecutive reactions, pathways, catabolic: Degrade nutrients: release energy and electrons that are accepted by carriers such as, anabolic: Convert small precursor molecules into larger, complex molecules. How activity of enzymes is controlled: reversible, we can modify the enzymes affecting the rate at which the reaction proceeds: Binding of a modulator at one site will either: Covalent modification: mostly reversible, enzyme which catalysis transfer of phosphoryl group from atp to acceptor enzyme, used in almost every metabolic process in eukaryotic cells, enzyme which catalyses dephosphorolation of enzyme, phosphatase, phosphoryl group, donor molecule: Typically atp: terminal phosphoral group transferred to a specific amino acid residue on the enzyme, eukaryotes: Three possible acceptor residues: serine, threonine, tyrosine, only occurs intracellularly, example, phosphorylation, control the amount of enzyme that is present in the cell: Synthesis more enzymes when a greater activity is required.
