BSC 2010 Chapter Notes - Chapter 12: Metabolomics, Metabolome, Proteome
23 Mar 2017
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Concept 12. 1 there are powerful methods for sequencing genomes and. Scientists can use genomic information in several ways: The genomes of different species can be compared to trace evolutionary relationships. The sequences of individuals within a species can be compared to identify mutations that affect particular phenotypes. The sequence information can be used to identify particular traits, such as genes associated with diseases. Human genome project: an enormous undertaking that was successfully completed in 2003; benefitted the development of sequencing of smaller genomes. Methods have been developed to rapidly sequence dna. Only one of the strands needs to be sequenced. Only several hundred bp can be sequenced at a time with the current methods; the key is to perform many sequencing reactions simultaneously after first breaking the dna into small, overlapping fragments. High-throughput sequencing: use miniaturization techniques first developed for the electronics industry, as well as the principles of dna replication and the polymerase chain reaction.
