BISC439 Chapter Notes - Chapter 4: Vimentin, Glial Fibrillary Acidic Protein, Lysosome
13 Feb 2017
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2 discrete functional domains in vertebrate neurons: axonal. Voltage sensitive ion channels at axon hillock: somatodendritic. Increased number of branches with development (decreases with ageing) Neurons and protein synthesis: critical to normal neuronal function, loci must be matched appropriately, produces myelin sheath, 2 categories of membrane proteins. Embedded in the lipid bilayer or bound covalently to molecules. Localized on the cytoplasmic surface of the membrane. Interact with membrane: through association with membrane lipids or, cytoplasmic tails of integral proteins or, by means of affinity for peripheral proteins. May bind to polar heads of lipid bilayer. Intermediate filaments: solid, ropelike fibrils, type v: nuclear lamins. Encoded by most evolutionarily divergent of filament genes. Has distinct pattern of introns and exons. Bisc 439 developmental neurobiology chapter 4: in the nervous system all produced by type iii or iv. Glial fibrillary acidic protein: marker for astrocytes and schwann cells. Disassemble easier under physiological conditions: means structures are probably more dynamic, important during development.
