BISC306 Chapter Notes - Chapter 6: Autocrine Signalling, Paracrine Signalling, Homeostasis

• School: University of Delaware
• Department: Biological Sciences
• Course: BISC306
• Professor: michael moore

Document Summary

Require interaction between membrane molecules on two cells. Acts on the same cell that secreted them. Secreted by one cell and diffused to other adjacent cells. Secreted by endocrine glands/cells into the blood. Only target cells with receptors for that hormone will respond to the signal. Diffuse across a small gap to the target cell. Electrochemical response neurotransmitter target cell response. Dna enzyme catalyze reactions determine outcome. Factories that determine the phenotype and metabolism of a cell. New enzymes can be made from dna. Activation of inactive enzyme by phosphorylation (addition of phosphate) Target cell must have receptor (binding protein) Binds to receptors in cytosol or nucleus. Activated receptors are gene transcription factors that bind to dna. This means it occurs on the outside of the cell. Binding of ligand receptor channel protein. Diffusion of ion through channel is a very rapid response by changing the membrane voltage. 40% of all prescription drugs target gpcrs as stimulants/inhibitors.