PNB 2250 Chapter Notes - Chapter 7: Bohr Effect, Urinary System, Ph

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Co2, terrestrial breathers & the evolution of respiration. Carbon dioxide: so much more soluble in water than oxygen. Possible to chemically modify co2 in such a way that more co2 can be produced/absorbed/etc: transport. When co2 is high, we make bicarbonate and acid. When bicarbonate and acid are low, we make carbon dioxide. Evolution of carbonic anhydrase activity and anion exchanger. Carbon dioxide can bind to hb and other proteins. A liter of blood can contain 550 ml of carbon dioxide. Need to lose carbons associated with glucose. Dramatically affects acid production within the body (more acid) Allows us to capture the energy stored in glucose. Blood must have buffering capacity to absorb h+ Buffering capacity based on weak acids and their salts (salts can soak up acids or us) Also rely on renal system to lose acid. Different problems arise for aquatic and terrestrial animals. Acid production is a negative consequence of producing carbon dioxide.

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