AH 3121 Chapter Notes - Chapter 10: Immune Privilege, Histocompatibility, Primary Biliary Cirrhosis
Document Summary
Avery welch ah 3121 immunology week 11 chapter 10 notes 11/10/15 & 11/12/15. Organ damage is irreversible or other treatments are not applicable. Disease must not recue: not recommended for goodpasture"s syndrome (anti-glomerular basement membrane ab) Comea no immunosuppression required because comea does not become vascularized: graft survival over 90% Kidney live related kidney donation often used; graft survival optimized by hla match: immunosuppression required, graft survival over 80% Pancreas usually transplanted along with kidneys in diabetics with renal failure; separated islet cells have also been infused into the vena cava: graft survival about 50% Heart used for coronary artery disease, cardiomyopathy ad some congenital heart disease: immunosuppression required, graft survival over 80% Liver used for alcoholic liver disease, primary biliary cirrhosis and virus-induced cirrhosis: graft survival over 60% Outcome not affected by degree of hla matching. Stem cells used in malignancy, hematological conditions and some primary immunodeficiency.
