MIMG 102 Chapter Notes - Chapter final: Tumor Suppressor Gene, Reassortment, Oncogene
20 Mar 2019
School
Course
Professor
Document Summary
2 questions (25pt each: polio, 1st part: polio & flu: t/f (10 questions, maybe 25% true or false???????) E. g. polio is enveloped: 2nd part: experimental. Study polio replication, translation, effect (translation inhibition) No pkr (but might be in part i) Read the entire question: know southern northern & western, flu, part a: one/two line (similar to reassortment but another slide, part b: bunch of viruses/rna: reassortment -> come up with phenotype/genotype. Difference between transducing & non-transducing: non-transducing: either integrate close to proto-oncogene or directly insert into tumor suppressor, transducing: pick up proto-oncogene. By recombination (copy choice) and then transcription: read thru (pol doesn"t stop & gene right after viral genome) Difference between simple & complex: accessory genes e. g. tat & rev, hiv: tat & rev are not accessory genes. Tat activates viral transcription (necessary for provirus transcription after integration) But can experimentally start transcription without it as long as you can make tf come.
