PSB 3002 Chapter Notes - Chapter 4: Sublingual Administration, Insufflation, Ventricular System
Document Summary
Intraperitoneal (ip) injection: injected through the abdominal walls into the peritoneal cavity (the space that surrounds the stomach, intestines, liver and other abdominal organs). Commonly used to administer drugs to small lab animals. Intramuscular (im) injection: directly into a large muscle (upper arm, thigh, or butt). Insufflation: (sniffing) cocaine and bath salts, delivers the drug to the brain very rapidly: differ from inhalation: enter the circulation through the mucous membrane of the nasal passages, not the lungs. Injected directly into the brain or into the cerebrospinal fluid of the brains ventricular system: past the blood-brain barrier by injecting the drug into a cerebral ventricle then absorbed into the brain tissue. Increasingly higher doses of a drug cause increasingly larger effects until the point of maximum effect is reached. (cid:455)(cid:373)pto(cid:373)s of parki(cid:374)so(cid:374)"s disease are due to death of dopa(cid:373)i(cid:374)e releasing cells in the substantia nigra: l-dopa: precursor for dopamine.
