MICROM 301 Chapter Notes - Chapter 16.1, 16.5, 16.6: Immunosuppression, Immunodeficiency, Vitamin K
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16. 1 the anatomical barriers as ecosystems: most microbes are harmless, many are beneficial, can cause disease if opportunity arises, delicate balancing act. To cause disease, most pathogens must first adhere to body surface and multiple. Iga proteases (1) enzymes that cleave iga antibodies. If body site has normal microbiota: new arrival must compete for space and nutrients, most also tolerate any toxic products such as fatty acids produced by the competitors. Iv: some gram negative pathogens deliver proteins directly into host cells using secretion systems, type iii secretion system. 1: syringe like structure that injects protein into eukaryotic cells. Induce changes such as (1) altering cells cytoskeleton structure: some direct host cell to engulf bacterial cell, several types of secretion systems discovered, some can inject molecules other than proteins. Invade generally by relying on skin damaging injury: most difficult anatomical barrier for microbes to penetrate.
