BSC 300 Chapter 17: Chapter 17 Textbook Notes
19 Apr 2018
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As f-actin filaments grow, the concentration of g-actin monomers decreases until equilibrium is reached between the filament ends and monomers, and a steady state is reached. Adp-pi-actin and then, after pi release, adp-actin subunits toward the (-) end. The concentration of capz in cells is generally sufficient to rapidly cap any newly formed (+) ends. Found predominantly in cells in which actin filaments need to be highly stabilized. Works with tropomyosin, which lies along the filament, to stabilize it. Binds to both tropomyosin and actin at the (-) end to greatly stabilize the filament. Section 17. 3: mechanisms of actin filament assembly: the rate-limiting step of actin polymerization is the formation of an initial actin nucleus from which a filament can grow. Formins are found in essentially all eukaryotic cells as a diverse family of proteins: seven different classes are present in vertebrates: all formin family members have two adjacent domains in common, the so-called fh1 and.
