BIOL 4376 Chapter Notes - Chapter 7: Oritavancin, Dalbavancin, Telavancin
22 Jun 2020
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Once a problem w older formulations, mississippi mud . Has re-emerged w higher doses: main uses (iv): mrsa infections, gram-pos infections in patients w severe beta-lactam allergy, & orally is drug of choice for c. diff. Fosfomycin: moa: inhibits production of monomers of peptidoglycan, bactericidal, moderately bioavailable, po in u. s. for utis, renally eliminated, given as one-time dose for utis, spectrum of activity: pseudomonas, other gnrs; gram-pos including staph, enterococci. Pseudomonas, acinetobacter, klebsiella: inactive against: serratia, providentia, rapidly bactericidal, adverse effects, nephrotoxicity very common, neutrotoxicity uncommon, uses: treatment of mdr gnr infections, topical infections, & prophylaxis of pneumonia in colonized cf patients. V a n c o m y c in l ip o g ly c o - p e p tid e s. D a p to m y c in p o ly m y x i n s f o s f o m y c in.
