CHEM 228 Chapter 16: Chapter 16 Book Notes
31 Jul 2016
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Overall reaction is exergonic because stability is retained. Alkylation and acylation of aromatic rings: the friedel-crafts reaction. An electrophilic aromatic substitution reaction to akylate or acylate an aromatic ring. These reactions don"t succeed on aromatic rings that are substituted either by a strongly electron-withdrawing group such as a carbonyl or a basic amino group. Dif cult to stop the reaction after a single substitution. Skeletal rearrangment of alkyl carbocation electrophile sometimes occurs during reaction. Acylated- introduction of an acyl group -cor, onto a molecule. For example, acylation of an amine yields an amide, and acylation of an aromatic ring yields an acyl aryl ketone. Substituents affect the reactivity of the aromatic ring: some make it more reactive and some make it less reactive. This orientations are usually not formed in equal amounts. An -oh group directs substitution toward the ortho and para positions . Cho directs substitution primarily toward the meta position.
