BCM 475 Chapter Notes - Chapter 22: Mitochondrial Biogenesis, Phosphocreatine, Acetyl-Coa
Document Summary
Increases insulin sensitivity by enhancing fatty acid metabolism. Increases fatty acid oxidation ability and adds extra mitochondria enhances fatty acid metabolism (increase [tag]) 2 changes in gene expression: enhances production of proteins for fatty acid metabolism (enzymes of b oxidation, transcription factors activated by ca2+ signal cascade increases mitochondrial biogenesis. Exercise releases ca2+ from sr during muscle contraction (ca2+ = second messenger, works with calmodulin) Ca2+ stimulates ampk, calmodulin-dependent pk which activate protein transcription factor complexes. Velocity of running depends on rate of atp production. Atp is generated more slowly from high-capacity stores (fats) than from limited ones (anaerobic, aerobic) Quick transfer of high-potential p to adp atp. Powers intense muscle contraction 5-6s: max speed is maintained for 5-6 seconds only. As [lactate] increases, the blood ph lowers this cannot be used in long-distance running. Complete oxidation of muscle glycogen to co2 by aerobic respiration is beneficial in long-distance.
