BCM 475 Chapter Notes - Chapter 22: Adenylyl Cyclase, Diglyceride, Glycerol
Document Summary
3 stages of processing lipid energy reserves (cid:3843). Lipid mobilization | triacylglycerol fatty acids + glycerol. Hormones: epinephrine, glucagon (released in body"s response to stressful situations/exercise) induce lipolysis. Bind to fat cells in adipose tissue to trigger 7tm receptors. Stimulates pka phosphorylates perilipin and hormone-sensitive lipase. Made of triacylglycerols and apoliprotein b-48 (apo b-48) transport fat-soluble vitamins and cholesterol. Bind to albumin (blood protein, carrier) to move through blood. Enter energy-requiring tissues and then fatty acid transport protein (across cell membranes) Absorbed/phosphorylated by liver: can undergo glycolysis pyruvate, can undergo gluconeogenesis glucose. Glycerol glycerol 3-phosphate dhap gap (catalyst = tpi) Glycerol and glycolytic intermediates are readily interconvertible. Activated by phosphorylation: restructures fat droplet (tags become more accessible, release of coactivator for adipose triglyceride lipase (atgl) Mag lipase converts mag final products: glycerol and fatty acids. Atgl = initiates mobilization of tags by releasing fatty acid from triacylglycerol diacylglycerol. Tag dag mag glycerol + fatty acid (cid:3844).
