BCM 475 Chapter Notes - Chapter 17: Acetyl-Coa, Thioester, Oxaloacetic Acid

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26 Nov 2016
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Final common pathway for oxidation of fuel molecules. Harvests high energy e- from fuel (acetyl coa) to electron carriers (nadh and fadh2) Acetyl coa + 3nad+ + fad + adp + p + 2h2o 2co2 + 3nadh + fadh2 + atp + 2h+ + coa. Source of precursors for building blocks (amino acids, nucleotides, porphyrin (heme): oxaloacetate precursor to glucose. Series of redox reactions that result in oxidation of acetyl group into 2co2. High energy e- reduce oxygen to water generates h+ gradient: used to synthesize atp. E- are taken and used to reduce nad+ and fad nadh and fadh2: acetyl unit becomes co2 and generates high energy e- for atp. 2 carbon molecules with the carbons coming directly from pyruvate. Under aerobic conditions, pyruvate acetyl coa (mitochondria) Condensation | oxaloacetate (4: and acetyl coa (2-c) Initially has only oxaloacetate active site (none for acetyl) Catalyzes condensation rxn by bringing substrates close, orienting them, and polarizing certain bonds.

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