PHYS 799 Chapter Notes - Chapter 19: Pituitary Adenoma, Pituitary Apoplexy, Sella Turcica
22 Apr 2019
Department
Course
Professor
Document Summary
* bolded text and tables were called out as need to know or were comments by dr. deyrup. Hypothyroidism: hypothyroidism caused by interference with the production of th, worldwide, most common cause is dietary iodine deficiency, but in developed nations, autoimmune causes predominate, clinical manifestations: cretinism and myxedema, cretinism hypothyroidism developed in infancy/childhood. Iodine deficiency endemic cretinism: enzyme defects in th synthesis sporadic cretinism. This leads to: ca reabsorption, increased urinary phosphate excretion, activation of vitamin d & higher gi calcium absorption, enchancement of ostoclastic activity: tumors usually come to attention due to excessive pth secretion, rather than mass effects. Hypoparathyroidism far less common: causes: surgically induced (most common), autoimmune hypoparathyroidism (aire [wk 7]), Congenital absence (di george syndrome, deletions on c22q11. 2: clinical: neuromuscular irritability, cardiac arrhythmias, occasional increased icp & seizures. Endocrine pancreas: beta cells produce insulin; alpha cells secrete glucagon; delta cells contain somatostatin. Other players in the adipo-insulin axis include ffas (which may cause lipotoxicity) and.
