BIOL 4087 Chapter : Biochemistry Extra Credit Paper
Document Summary
Rna along with dna and proteins are essential for all forms of life. Researchers are realizing alternative targets in rna are necessary so they can address the growing. The key to rna targeting is by directing functional dynamics of rna is through some basic interactions such as: electrostatic interactions, non-ionic interactions, pseudobase pair interactions and water mediated interactions. There is no set of rules to describe the properties of rna binding molecules and no focused small molecule libraries that can be used for screening rna. Mr. boyapati used a fragment-based approach in the hopes to better understand this topic. This fragment-based approach contained a series of steps to help him identify his rna targets. The first step was the assembly of a ligand database in which the rna binding ligands were identified from literature. He chose ligands that interact with rna under a kd value of 50 um. Next was the fragmenting of these chosen ligands where mr.
