BIOL 4087 Chapter : Chapter 4
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Character: peptide bonds are planar, secondary structure: local ordered structure , * stabilized by h-bonds , fig 4-4 a,b,c,d, helix : is a right handed helix , that is tightly wound. In an helix there is no proline b/c : proline is stiff and kinks, proline cant h-bond, need opposite charge fig 4-4-d, helix has dipole fig 4-5, this helix dipole stabalizes the. Proline is used to make: b- sheet decreased solubility to proteases, prion disease : disease caused by abnormally formed protein(has more b shrrt) examples: mad cow, cruzefelt -jakob. 3 tertiary structure: the 3d structure of a single poly peptide, seen by x-ray and nmr. Fig 4-14 -> human serum albumin (585 aa in a single chain) Fig 4-16- heme a prosthetic group: metal ion or organic molecule bound to a. Fig 4-15 a&b -> myoglobin ribbon diagram protein that is required for activity. Fig 4-17 a&b is an example of super secondary structure)