BIOL 3090 Chapter : Test 3 Study Guide

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15 Mar 2019
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Study guide for exam 3: gene knockout in yeast (fig. Pcr product with ends homologous to target gene: gene knockout in mouse, and the construction of a transgenic mouse (from dna cutting and pasting, to es cells, to blastocysts, to mendelian genetics). (fig. Note: keep in mind that the herpes simplex viral thymidine kinase enzyme converts ganciclovir into a toxic compound that kills the cells that still retain the tkhsv gene. Cells that lack the tkhsv gene due to homologous recombination survives in the presence of ganciclovir. Es cells taken from blastocyst mouse embryos (totipotent, easily cultured, easily transfected) Gfp distributes randomly within those cells that actually use this specific promoter. Defective chloride channel in epithelial cells leads to excessive mucus in lungs. Defective cytoskeletal protein dystrophin leads to impaired muscle function. Restriction fragment length polymorphisms used as physical markers on chromosomes. 10,000 different polymorphisms have been mapped in the human genome: what is linkage disequilibrium and what does t. h.

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