BIOL 1201 Chapter : BIOL 1201 3 22
Document Summary
Transforming bacteria: cause non-virulent bacteria to become virulent. The transforming principle: avery, maccleod and mccarty in 1944 demonstrated that dna was the transforming principle. Dna as the genetic material: studies with viruses (bacteriophages-bacteria eaters, hershey and chase, 1952, used the bacteriophage t2, sulfur in proteins, phosphate in dna. 2-deoxyribonucleic acid: alfred mirsky-1950, equal amounts of dna in each somatic cell of a species, thee constancy of dna, chargaff-1950, a/t and g/c ratios. G=c: watson and crick, 1953, dna structure and the implication for dna replication, insights from wilkins and franklin x-ray data: dna is a double helix of uniform width. Dna: double helix, anti-parallel, base pairing with hydrogen bonds. Pairing of bases from the different strands: a-t, two hydrogen bonds, g-c, three hydrogen bonds. Semi-conservative replication: each strand of the original double helix serves as a template for a new complementary strand, meselson and stahl experiment.
