AGRI 1005 Chapter : Hgp Wrap Up
Document Summary
The impact of the cancer genome project and high-throughput analyses on personalized oncology: today and tomorrow: european society for medical oncology 2012. Published by oxford university press on behalf of the european society for. Authors affiliations: genetics, institute for cancer research, the norwegian radium hospital, oslo. Breast cancer (bc) is a complex disease caused by accumulation of genetic alterations leading to a disturbed balance between proliferation and apoptosis, genetic instability and acquisition of an invasive and resistant phenotype. The inherent heterogeneity, including the microenvironment, contributes to each tumors phenotype and dictate tumors molecular portraits. We have generated high-throughput data of tumors from mrna and mirna expression, snp-cgh and dna- methylation, paired-end sequencing, protein expression by rppa, and metabolic profiles from. We have explored to which extent combining the various profiles derived from each level, can further subdivide the initially discovered expression subclasses and improve prognostic potential.
