AS.020.305 Chapter 8: Exam 2 Notes (dragged) 14
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The water-soluble ip3 stimulates the release of ca2+ sequestered in the endoplasmic reticulum (4), which in turn activates numerous cellular processes through the intermediacy of calmodulin (cam; 5). Dag remains associated with the membrane, where it activates protein kinase c (pkc) to phosphorylate and thereby modulate the activities of a number of cellular proteins (6). Pseudosubstrate sequence (red) that binds at or near the enzyme"s active site (brown) so as to inhibit its function. The autoinhibitory segment is in close proximity with or overlaps a ca2+ cam binding sequence.
