BSC 203 Chapter Notes - Chapter 2: Critical Role, Peptide, G Protein–Coupled Receptor

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19 Sep 2017

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Slide 1: in this presentation, i will be discussing an overview and the basics of cell signaling. I will discuss the two types of cellular receptors, g protein-coupled receptors and receptor tyrosine kinase. Slide 2: to being i will discuss the two types of receptors. The two types of cellular receptors are: intracellular receptors and cell- surface receptors. Intracellular receptors are located inside the cell instead of on the cell membrane. These bind small or lipophilic molecules such as steroid hormones. The location of these receptors aid in allowing the inhibitory protein to leave the cell. They also allow for a coactivator protein to bind and for binding within the dna sequence for initiation of gene transcription. Slide 3: the second type of receptors are the cell-surface receptors. They are found in the cell membrane and bind to extracellular molecules. They are specialized integral membrane proteins that allow communication between the cell and the extracellular space.

Related Questions

1. Which cellular processes occur as a consequence of differential control of gene expression in eukaryotic cells?

a) Cell Differentiation

b) Differential Translation

c) Differential Polymerization

d) Differential DNA Replication

e) Differential tRNA Degradation

2) Multicellular organisms are comprised of a variety of cells with different morphologies and different functions. Which is the underlying mechanism that leads to the generation of diverse cell in one organism?

a) The expression of all genes in all cell types.

b) The duplication of the genome in certain cell types.

c) The elimination of specific group of genes from different cell types.

d) The differential expression of particular sets of genes required for a particular cellular phenotype

e) All of the above

3) Which of these statements defines paracrine cell signaling?

a)		A messenger molecule released into the blood stream to bind to a receptor on a cell far away from the release site.
b)		A messenger molecule released by a cell into the extracellular space that binds to receptors on the surface of the same cell.
c)		A messenger molecules released by a cell into the extracellular space that travels short distances to bind to a receptor in a nearby cell.
d)		A messenger molecule release by a tissue into the lumen of an organ that diffuse to bind to receptors far away from the release site.
e)		All of the above.

4) Which effect has the binding of the ligand to a G-protein coupled receptor on intracellular G-protein?

a)		ATP is hydrolyzed, activating phosphorylation
b)		GTP is exchanged for GDP on the G protein, inactivating the G protein
c)		GDP is exchanged for GTP on the G protein, activating the G protein
d)		GMP is released from the G-protein, inactivating the receptor
e)		None of the above

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QUESTION 1

Which of the following is an example of an extracellular signal molecule?

	a.	IP₃
	b.	cAMP
	c.	Insulin
	d.	Diacylglycerol

2 points

QUESTION 2

Nuclear hormone receptors _____

	a.	Bind to water soluble ligands
	b.	Activate second messengers
	c.	Regulate transcription in response to ligand binding
	d.	Are normally located on the plasma membrane

2 points

QUESTION 3

Which of the following does not occur when a receptor tyrosine kinase is bound by ligand?

	a.	Phosphorylation of the RTK
	b.	Cytoplasmic proteins bind the phosphorylated RTK
	c.	Dimerization of the RTK
	d.	The RTK binds to DNA to regulate transcription

2 points

QUESTION 4

Which of these is a logical signal-transduction pathway?

	a.	An intracellular receptor activates phospholipase C, which cleaves a membrane protein to form IP₃, which then activates the opening of an ER channel protein, which releases cyclic AMP into the cytoplasm, where it binds to an intracellular enzyme that carries out a response.
	b.	A G-protein-linked receptor activates G protein, which activates phospholipase C, which cleaves a membrane lipid to form IP₃, which binds to a calcium channel on the ER, which opens to release calcium ions into the cytoplasm, which bind to an intracellular enzyme that carries out a response.
	c.	An ion-channel receptor opens, allowing a steroid hormone to enter the cell; the steroid hormone then activates protein kinases that convert GTP to GDP, which binds to an intracellular enzyme that carries out a response.
	d.	A tyrosine-kinase receptor activates adenylyl cyclase, which activates phospholipase C, which converts ATP into cyclic AMP, which binds to an intracellular enzyme that carries out a response.

2 points

QUESTION 5

Which of the following is an example of signal amplification?

	a.	activation of an enzyme molecule
	b.	activation of a specific gene by a growth factor
	c.	Breakdown of many cAMP molecules
	d.	activation of 100 molecules by a single signal binding event

2 points

QUESTION 6

Consider a signal transduction pathway that utilizes cAMP as a second messenger to activate PKA (Protein Kinase A). Which of the following situations will result in the cellular response?

		The G protein releases GDP and binds to GTP
		The target protein (adenylyl cyclase) is inactive
		The regulatory subunits of PKA (Protein Kinase A) are bound to the catalytic subunits
		The appropriate G protein is bound to GDP

2 points

QUESTION 7

Which of the following is found in only some signal transduction pathways? [In other words, which is not found in all signal transduction pathways?]

		Receptor protein
		Extracellular signal molecule
		Intracellular signaling molecule
		Cellular response
		Effector protein

2 points

QUESTION 8

The enzyme that specifically catalyzes the conversion of ATP to cAMP is:

		Adenylyl phosphatase
		Adenylyl kinase
		Adenylyl dehydrogenase
		Adenylyl cyclase

2 points

QUESTION 9

If an animal cell suddenly lost the ability to produce GTP, what might happen to its signaling system?

		It would use ATP instead of GTP to activate and inactivate the G protein on the cytoplasmic side of the plasma membrane.
		It would not be able to activate and inactivate the G protein on the cytoplasmic side of the plasma membrane.
		It would employ a transduction pathway directly from an external messenger.
		It would be able to carry out reception and transduction but would not be able to respond to a signal.

2 points

QUESTION 10

A hormone signal is sent from the brain to other parts of the body via the bloodstream. Why do only certain cells respond to this signal?

		Hormones do not last long enough in the bloodstream to stimulate a cellular response
		Only cells that have a specific transcription factor gene will be able to respond to the signal
		Only cells in the immediate vicinity of the cell sending the signal will respond
		Only cells that have a receptor for the specific signal will be able to respond to it

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What is a caveolae?

A) âBubblesâ found on the surface of the plasma membrane
B) Small invaginations of the plasma membrane
C) Invaginations of the rough ER
D) Specialized vesicles

Using Figure 1, how many ways can estrogen signaling beinitiated in vascular endothelial cells (ECS)?

A) One
B) Four
C) Three
D) Two

What was one of the results scientists found after activation ofthe membrane-bound estrogen receptor?

A) Vascular protective effects
B) Accelerated cancerous growth in breast tissue
C) Stimulation of cell division in breast/uterine tissue
D) Accelerated cancerous growth in uterine tissue

Using the description of Fig. 1, how do ligand-activatedtranscription factors function?

A) They are membrane bound receptors that bind estrogen as aligand.
B) They are imported into the nucleus as dimers afterligand-binding and then help initiation transcription.
C) None of these are correct.
D) They are always bound to the DNA, but require ligand binding tofunction.

What is one result of estrogen binding a membrane-bound estrogenreceptor in vascular tissue, thereby activating the rapid,non-nuclear signaling pathway?

A) Decreased cell growth
B) Decreased cell migration
C) Production of nitric oxide

The membrane-bound estrogen receptor is located________________.

A) somewhere in the membrane (i.e., researchers do not know theanswer)
B) as a transmembrane protein
C) on the intracellular leaflet of the membrane
D) on the extracellular leaflet of the membrane

The timing of estrogen therapy during menopause in women mayaffect the role estrogen plays in the cardiovascular system.

A) True
B) False

What ligand is used in this study to activate the membrane-boundestrogen receptor?

A) A G-protein
B) Estrogen dendimer conjugate (EDC)
C) Nitric oxide
D) 17b-Estrogen

Does estrogen dendimer conjugate (EDC) activate estrogenreceptors that are non-membrane bound (i.e., cytoplasmic ornuclear)?

A) No
B) Yes

10.

The ligand EDC causes cell migration and proliferation in whichof the following tissues? (Check all that apply)

A) Vascular (i.e., vessel) tissue
B) Ovarian tissue
C) Breast tissue
D) Uterine tissue

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BSC 203 Chapter Notes - Chapter 2: Critical Role, Peptide, G Protein–Coupled Receptor

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