PSYC 2050 Chapter Notes - Chapter 8: Valproate, Iproniazid, Reserpine
8 Jan 2018
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Treats bipolar 1, epilepsy, seizures, and migraines. Decreases the firing of action potentials: major depressive disorders. Monoamine theory of depression (serotonin, norepinephrine, dopamine): reserpine . When you limit monoamine, people get sad; iproniazid inhibitor of mao (not able to break down neurotransmitter), increased people"s mood. More neurotransmitters in the synapse with medication: schizophrenia. Bleuler (1911): shattered mind = split mind . Symptoms: delusions, hallucinations, disorganized speech, catatonic behavior, negative symptoms (social withdrawal, decreased speed in speech and/or movement) Dopamine hypothesis: high doses of cocaine and meth; antipsychotics block receptors for dopamine. Glutamate hypothesis: ketamine, pcp block glutamate; better theory compared to dopamine hypothesis: antipsychotics. Conventional: phenothiazines; effects are similar to parkinson"s disease; blocks dopamine receptors. Atypical: all antipsychotics introduced in the past 10 years; serotonin-dopamine antagonists. Tardive dyskinesia is the most serious complication of antipsychotic treatment.
