BIOL 4570 Chapter Notes - Chapter 16: Programmed Cell Death, Janus Kinase, Lipopolysaccharide
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Ctla4: reduces costimulation of t cells by binding to b7 molecules and blocking their interactions with cd28 used to treat patients with rheumatoid arthritis who fail to respond to anti tnf alpha therapy. 16. 2 cytotoxic drugs cause immunosuppression by killing dividing cells and have serious side. Effects: 3 cytotoxic drugs most commonly used as immunosuppressants are azathioprine, cyclophosphamide, and mycophenolate. Jaks bind and phosphorylate cytoplasmic regions of cytokine receptors and initiate activation of different stat transcription factors. Jak inhibitors ~ black kinase activity of one or more developed over last decade that can block kinase activity of one or more members of this family. 16. 4 antibodies against cell surface molecules can be used to eliminate lymphocyte subsets or to. 16. 7 depletion of autoreactive lymphocytes can treat autoimmune disease: rituximab ~ anti cd20 monoclonal antibody; originally developed to treat b cell lymphomas, but has also been tried in treating certain autoimmune diseases.
