BIOL 4570 Chapter Notes - Chapter 4: B-Cell Receptor, Mhc Restriction, Immunoglobulin G
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Chapter 4 antigen recognition by b-cell and t-cell receptors: antigens ~ any molecule or part of molecule that is specifically recognized by highly specialized recognition proteins of lymphocytes. 4. 1 igg antibodies consist of four polypeptide chains. Igg antibodies are large molecules with molecular weight of approximately 150 kda and are composed of 2 different kinds of polypeptide chains: heavy / h chain ~ 50 kda, light / l chains ~ 25 kda. Isotypes ~ 5 main heavy chain classes; determine functional activity of antibody molecule. 4. 2 immunoglobulin heavy and light chains are composed of constant and variable regions: each chain consists of series of similar but not identical sequences, each about 110 aa long. 4. 4 immunoglobulin molecule is flexible, especially in hinge region: haptens ~ flexibility is revealed by studies of antibodies bound to small antigens; molecules of various types that are typically about size of tyrosine side chain. Immunoglobulin fold ~ distinctive folded structure of ig protein domain.
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1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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