BIOL 4570 Chapter Notes - Chapter 5: Hypervariable Region, Beta Sheet, Immunoglobulin Light Chain

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27 Feb 2020
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Chapter 5 generation of lymphocyte antigen receptors: variable regions ~ in ig, there are heavy chain and light chain variable regions; in t cells they are alpha and beta regions. 5. 1 immunoglobulin genes are rearranged in progenitors of antibody producing cells. Immunoglobulin fold ~ composed of 9 beta sheets; variable regions of ig heavy and light chains: antibody binding site is formed by 3 loops of aas known as hypervariable regions hv1, Joining or j gene segment ~ where variable or v gene segment originates: v region gene ~ refers to exon encoding complete variable regions formed by. 5. 2 complete genes that encode variable region are generated by somatic recombination of splicing together of gene segments. Separate gene segments: diversity or dh gene segment ~ lies between vh and jh gene segments. 5. 7 multiple inherited gene segments are used in different combinations. Intergenic control regions ~ activates v (d) j recombination in developing b cells.

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