BIOL 3450 Chapter 19: Chapter 19 – Eukaryotic Cell Cycle

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4 Jun 2019
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19. 1 overview of cell cycle and its control. Cell cycle is ordered series of events leading to cell replication: g1 phase ~ cycling (replicating) mammalian somatic cells grow in size and synthesizing. Cyclin- dependent kinases control eukaryotic cell cycle cells: cyclin dependent kinases (cdks) ~ no kinase activity unless associated with regulatory cyclin subunit; determine substrate specificity of complex (which proteins phosphorylate) Several key principles govern cell cycle: positive feedback ~ specific cdks promote own activation, negative feedback mechanisms ~ indirectly or with built in delay; cdks promote their own inactivation. 19. 2 model organisms and methods of studying cell cycle. 19. 4 commitment to cell cycle and dna replication. Cells are irreversibly committed to division at cell cycle point called start or restriction. Point: start ~ transition point in late g1 phase, restriction point ~ cells become refractory to growth factor signals and proliferation inhibitor signals.

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