PSYC 335 Chapter Notes - Chapter 1-4: Allyn & Bacon, Metabotropic Glutamate Receptor, Muscarinic Acetylcholine Receptor
23 Jan 2016
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Neuromodulators n neurotransmitter binding to receptors produces either epsps or ipsps l glutamate produces epsps l gaba produces ipsps n neuromodulators alter the action of systems of neurons that transmit information using either glutamate or gaba. Synthesis of ach n ach synthesis pathway: l acetyl coa+choline . Ach l coa arises from glucose metabolism l synthesis is dependent on choline l ach synthesis is blocked by nvp. 5-ht: release and termination n serotonin release: l 8-ohdpat is an autoreceptor agonist that reduces. 5-ht release l no selective release blocker l fen uramine is a 5-ht releasing drug n serotonin termination: l reuptake is blocked by uoxetine (elevates 5ht) l degradation: mao converts serotonin to 5- Gaba n gaba is synthesized from glutamic acid n gaba induces ipsps n gaba acts via 2 receptors l gabaa: ionotropic receptor (controls a chloride channel) l gabaa receptors contain 5 distinct binding sites gaba site.
