BIOL 121 Chapter Notes - Chapter 1: Collecting Duct System, Renal Function, Distal Convoluted Tubule

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22 Dec 2020
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Filtration in the kidneys begins with the renal corpuscles in cortex, each of which contain a glomerulus, a compact ball of connected capillaries connected to an afferent and efferent arterioles. Each renal corpuscle also contains a bowman"s capsule, between these two components of the renal corpuscles, bowman"s space (fluid-filled space) is where glomerular filtration occurs as protein-free fluid enters from the capillaries into bowman"s space. Protein- free fluid travels through the endothelial cells of the capillaries through the basement membrane to the cells of the inner lining of bowman"s capsule, called podocytes which contain foot processes. Gfp = pgc pbs - gc . At any given gfp, the glomerular filtration rate will be directly proportional to the membrane permeability and the sa. Gfr can be altered via neural (sympathetic/parasympathetic) or hormonal (epi) influences. For example, is the afferent arteriole leading to the glomerulus is constricted, pressure in the capillary (pgc) will decrease, causing a decrease in gfr.

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