BSC 1010 Chapter Notes - Chapter 21: Telomerase, Telomere, Apoptosis
29 Aug 2020
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Document Summary
Carcinomas arise from epithelial cells covering external & internal body surfaces: ~90% of all cancers. Tumors arise when the balance between cell division and cell differentiation or death is. Cancer type of growth in which some cells divide and accumulate in an uncontrolled way: the resulting mass of tissues is called a tumor (neoplasm) When tissue stem cells divide to replace dying cells cell division must be balanced with cell differentiation and cell death: prevent the accumulation of dividing cells, this balance is disrupted in tumors. Normal cells do not grow well in culture unless provided with a solid surface they can attach to. Cancer cells can grow well in suspension: anchorage-independent growth. Cancer cell proliferation is insensitive to population density. Unlike normal cells, cancer cells do not respond to inhibitory influences (e. g. contact with other cells, depletion of growth factors: normal cells grow in a monolayer (density dependent inhibition of growth, cancer cells grow in clumps.
