PSYCH-230 Chapter Notes - Chapter 1: Mood Disorder, Bipolar Disorder, Neurotrophic Factors
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Bipolar disorder is one of the most heritable of disorders. Concordance rate for bipolar is as high as 85% Genes account for possibly 85% of the variance in where a person becomes manic. Genetic factors don"t determine when manic symptoms occur. Risk of mania is apparently also related to a higher risk for depression. Information on mdd indicates that genetic factors are not as decisive as they are in bipolar disorder. Relatives of mdd probands are at a somewhat increased risk for mdd, but the risk is less than the risk for relatives of bipolar probands. Old study found linkage of dominant gene on the 11th chromosome to bipolar but it hasn"t been replicated. No signi cant ndings for genome-wide association studies with depression. Bdnf gene appeared to predict risk for developing rapid cycling, but subsequent research was inconsistent. People who possess one or two copies of the short variant of the 5-
