HESC 401 Chapter Notes - Chapter 7: Blind Experiment, Pre-Clinical Development, Design Issues
15 Oct 2016
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To describe the important elements of randomized trials. To define the purpose of randomization and of masking. To introduce design issues related to randomized trials, including stratified randomization, planned and unplanned crossovers, and factorial design. To illustrate the problems posed by noncompliance in randomized trials. (cid:862)the ra(cid:374)do(cid:373)ized trial is co(cid:374)sidered the ideal design for evaluating both the effecti(cid:448)e(cid:374)ess a(cid:374)d the side effects of (cid:374)e(cid:449) for(cid:373)s of i(cid:374)ter(cid:448)e(cid:374)tio(cid:374). (cid:863) Randomized trials are also an effective tool in non-clinical studies, such as community based trials (in this case, they are referred to merely as randomized trials rather than rct: randomized clinical trials). Randomized trials are used for: evaluating new drugs/treatments for disease, assessing new programs for screening and detection, assessing new ways of organizing and delivering health services. A randomized trial begins with a study population that is divided into two groups: One group receives the new treatment being studied.
