BIOL 118 Chapter Notes - Chapter 19: Chromatin Remodeling, Tata Box, Histone Deacetylase
26 Apr 2017
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Figure 19. 2 (frankie needs to add his notes up to here) Genes can only be transcribed when they"re loosely packed together. Cant have tigtly packaged because machinery cant do its job - at most must be in nucleosome. Causes chromatin to condense - adding methyl groups to cytosein in dna. In mammals, recognize a c next to a g (cpg) : p stands for phosphate group between them. Age of father and diseases that their offspring get - the c are methylated not the g. Acetylation if histones is usually associated with the activation of genes. Histone acretltransferases (hats) add acetyl groups to histones, decondensing the chromatin - good for transcritption. Histone deacetylases (hdacs) remove them leading to chromatin conensation. Eipigenetic inheritance - any inheritance mechanisms that is not due to differences in dna sequences. Epigenetic mechanisms can record life events that infleunce phenotypes of offspring. Rna polymerase binds at the core promoter - must bind there.
