PHIL 2015 Chapter Notes - Chapter 3.5: Mifepristone, Basal Metabolic Rate, Corpus Luteum
23 May 2020
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Two isoforms encoded by different genes: er and er : maintenance of reproductive systems (uterine, breast) Medroxy- progesterone contraceptives work by sustaining the levels of sex steroids to trick the body into thinking it"s pregnant. Pr-a (endometrial) and pr-b (breast: uterine and reproductive development (pr-a) inhibition of endometrial cell proliferation, mammary gland development (pr- Tr 2: widely expressed but does not bind to hormone. Tr 2: hypothalamus, pituitary (negative feedback of hp-axis: maintains basal metabolic rate. Note: mifepristone is non-selective and will antagonize both the pr and gr. Note: however, propylthiouracil and methimazole inhibit production of thyroid hormones and have. 1,25-dihydroxyvitamin-d3 (calcitriol: regulation of ca2+ and po4. Nuclear localization fatty acids, eicosanoids, prostaglandins thromboxane a2 (txa2) Salt and water balance mostly by increasing na+ reabsorption in dct: mr is also activated by cortisol, fludrocortisone (addison"s disease) which is 100x more abundant than aldosterone.
