HIST 3791 Chapter Notes - Chapter 4.6: Urethral Stricture, Gonorrhea, Neisseria
Document Summary
Have surface pili on their membrane which prevents them from phagocytosing easy access to endotheial areas. Pili containg iga protease attack iga on mm. Adhere to surface of spermoatoza access/transmission to fallopian tubes. Symptomatic pts not treated become asymptomativ in 6months: untreated infections fibrosis, urethral stricture, fallopian tube stricture, Ft/ovarian abscess, pid (15%) & infertility: can also get disseminated infections, necrotic skin lesions, arthritis. Can be transferred to baby at time of delivery conjunctiva infection. Complications: pid (infertility, ectopic preg), disseminated gonorrhea (3x more common than males) Diagnosis for gonorrhea sx w. in 2-8 days after sex. Culture & sensitivity testing from urethral smear from male. Culture & sensitivity low sensitivity from cervix, anus, and pharyngeal swab. N. gonorrhoeae has the ability to develop resistance pump that pumps out. In canada do not use the following abx (b/c of high resistance: pcns, tetracyclines, quinolones. Spectinomycin 2g im (single dose) plus azithromycin 1g po single dose.
