BIOL 3051 Chapter Notes - Chapter 5.0: Slc22A1, Transporter 3, Transporter 2

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lavendershark790

6 May 2020

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Apical: mdr1/p-gp, mrp2, bcrp, asbt, pept1, oatp, mct1, oct1, nt, npt, amino acid transporter. Efflux: mrp3/4, ntcp, oatp, mct2, oat2, oct1, nt. Oral absorption (small intestine: apical transporters: absorption (intestine enterocyte) Oligopeptide transporter 1: 3o active transporter, peptide bond conservation, oatp2b1 & oatp1a2. Organic cation transporter 1: di-/tripeptides, peptidomimetics ( -lactams, amino- cephalosporins, ace inhibitors, steroid conjugates (estrone-1-sulfate, statins (pravastatins, hiv protease inhibitors (e. g. ritonavir, saquainavir) Ghb: endogenous cations, antivirals (e. g. acyclovir, ganciclovir) taurocholate cefixime pravastatin salicylic acid ganciclovir caffeine (purine) fosfomycin cycloserine, nt. Nucleoside transporter: purines (allopurinal, azathioprine, caffeine, pyrimidines, uracil (5-fluorouracil, nucleotides, npt. Na-phosphate transporter: sodium phosphate salts (fosfomycin, foscarnet, amino acid. Transporter: amino acids & analogues (gabapentin, baclofen, d-cycloserine, l-dopa, methyldopa) 4: apical efflux transporters (enterocyte intestine) 1-sulfate: anticancer drugs (topotecan, mitoxantrone, methotrexate, vinblastine) vinblastine acetominophen sulfate estrone sulfate, basolateral efflux transporters (enterocyte blood) Hepatic transporters: sinusoidal influx transporters (blood hepatocyte) Na-dependent taurocholate co-transporting polypeptide: majority of bile acid transport.

Related Questions

Use they key to answer each group of matching questions ?

Key: FAT ,PROTEIN, NUCLEIC ACID, STARCH

1.Adenine -

2.Glucose-

3.Amino Acid

4.Glycerol

Key : DNA, RNA BOTH, NEITHER

5.double helix - 6.Ribose-

7 .Nucleic Acid-

8.Uracil-

azurehound969

QUESTION 1

Ion diffusion across plasma membrane needs

		a concentration gradient across the membrane
		specific transporters
		ATP
		provide extra energy for the transport

2 points

QUESTION 2

There are four types of large biological molecules

2 points

QUESTION 3

Active transporters transport substances across cell membrane against ____________

2 points

QUESTION 4

Which of the following is a nonpolar amino acid?

	1.	Valine
	2.	Serine
	3.	Aspartic acid
	4.	Glutamic acid

2 points

QUESTION 5

Membrane potential of a cell is created by:

	1.	sodium ion concentration difference between inside and outside of the cell
	2.	a difference in protein concentration across the cell membrane
	3.	an electrical potential difference between the intracellular fluid and the surrounding extracellular fluid
	4.	a difference between the potassium concentration inside and outside of the cell

2 points

QUESTION 6

A mutation resulted in a change from a valine to a glutamic acid in a peptide sequence. This mutation will NOT change the protein folding

True

False

2 points

QUESTION 7

Ions can be transported across plasma membrane by

	1.	diffusion
	2.	No need of transporters
	3.	osmosis
	4.	active transport

2 points

QUESTION 8

Phospholipid is composed of

	1.	A glycerol backbone
	2.	One protein group
	3.	One carbohydrate group
	4.	Two fatty acid chains and one phosphate group

2 points

QUESTION 9

Prokaryotic cells and eukaryotic cells are similar in

	1.	Plasma membrane
	2.	nucleus
	3.	mechanism for protein translation
	4.	endoplasmic reticulum

2 points

QUESTION 10

Disulfide bonds are formed between two histidine residues

True

False

Thinking about macromolecules and how their monomers come together to form the polymer match the following. A. glycosidic bonds B. phosphodiester C. ester bonds D. peptide bonds E. monosaccharaides F. amino acids G. nucleotides

1. Monomeric units of protein

2. Monomeric units of DNA

3. Monomeric units of carbohydrates

4. Monomeric units of a lipid

5. Proteins are held together by

6. The bond type that joins adjacent monomers in DNA and RNA

7. Carbohydrates like glycogen are formed by the bonding glucose molecules together via

8. The glycerol backbone of a lipid is bonded to the fatty acid tails by

9. These monomers have a amino group on one end and a carboxylic acid on the other.

10. Î±1-4 and Î²1-4 are two different types of this bond.

BIOL 3051 Chapter Notes - Chapter 5.0: Slc22A1, Transporter 3, Transporter 2

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