BIOL 3051 Chapter Notes - Chapter 11.0: Zinc Finger, Dna-Binding Domain, Response Element
24 Apr 2020
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Dna binding & dimerization zinc fingers: dbd binds to the dna. Dbd is single globular domain: dna recognition helix- allows you to see sequences of h-binding. Identity of these amino acids in dna recognition is what tells it what nucleotides sequences is there. Nuclear receptor dna response element: steroid receptors, you have gs in p-box binds to sequence. Agaaca: other receptors, you have eg in p-box binds to sequence. Aggtca: these 2 aa (p-box) dictates sequence of dna it binds to, agaaca & aggtca are half-sites. Dbd specificity: receptor has 2 zinc fingers w/p-box & d-box, p-box of receptor: binding-motif specific, d-box of receptor: dimerization specificity. Nuclear receptors can bind to dna as: homodimers: gr, mr, pr, ar, er, heterodimers: ppar, vdr, tr, rar, lxr, fxr, pxr, car with. Types of response elements: types of response elements differ based on if it"s a homodimer or heterodimer, homodimers could be inverted or everted receptors bind to different dna strands.
