BIOL 3051 Chapter Notes - Chapter 6.3: Veratridine, Conotoxin, Tetrodotoxin
24 Apr 2020
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If cell is held at potential for infinite period, fraction of total vgc will inactivated. More depolarized vm (+), more channels inactivated. Minfinity curve: activation curve: vgscs can activated before reaching activation threshold for vm. As you go from more depolarized potential, you get less current. As you move towards positive end, there"re more channels in inactive state. More negative cell is, the inactivation gate opens. Even at negative potential, channels could be inactive. Na+ receptor can have many toxins: tetrodotoxin, batrachotoxin, anthopleurin b. conotoxin, pro-tx2, od1 site on alpha subunits of na, neurotoxin site 1: bind to non-peptide blocker. Higher concentration of ttx, more inhibition of na+ current. Drug blocks channel pore inhibit current: neurotoxin site 2: binds to lipid-soluble toxins: batrochotoxin, (btx), veratridine, aconitidne, grauantoxin. Enhance activation of vgscs, make more excitable by making it more hyperpolarize. Even at rest may have activation of these channels. More negative threshold potential (vm) required for ap.
