BIOL 3051 Chapter Notes - Chapter 4.1: Nonsteroidal Anti-Inflammatory Drug, Paracetamol, Duloxetine
20 Apr 2020
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Major classes: simple analgesic (acetaminophen, nsaids (oral/ topical, snri (duloxetine, analgesic opioids, corticosteroids (intra-articular injections, topical capsaicin, glucosamine/chondroitin, hyaluronans (injections, platelet-rich plasma. Compare efficacy based on: symptom and pain relief. Nsaids > acetaminophen: long term treatment with acetaminophen is no different than placebo, acetaminophen not very effective for knee oa. Oral ~ topical nsaids almost same efficacy: topical nsaids (for knees and hands, oral nsaids (for knees, hips, and hands) Intra-articular injections (for knees, hands, and hips: which nsaid depends on location of oa e. g. we don"t want to put topical nsaid on hand because it will get washed off due to constant hand washing. Opioids don"t have a big role here. Glucosamine and chondroitin not lot of data supporting efficacy. Oral nsaids & propionic acid derivatives fastest acting (30-60 mins) Topical nsaids take 1-2 days to act. Cost and convenience overview: confusion, dizziness, drowsiness, headache.
