BIOL 1000 Chapter Notes - Chapter 12: Polynucleotide, Histone H2B, Deoxyribose
22 Apr 2014
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12. 2 dna structure: x-ray diffusion when x-rays are focused through isolated macromolecules or crystals of purified molecule, the x-rays deflected are in patterns called diffraction patterns. Provides info about organization of the molecular components. T & a as well as g & c were present in dna with fixed interrelationship. The two strands of a parental dna molecule unwind and each serves as a template for the synthesis of a complimentary copy. Base pair specificity provides basis for duplication. 3 types of replication: semiconservative, conservative parental strand remains intact, dispersive parental strand & progeny become intertwined through fragmentation, synthesis, and rejoining process. Before replication: primer function (primase) adds rna primer on template strand to initiate replication. Used as a starting point for nucleotide assembly by dna polymerases: template provides ssdna (single-stranded) that will direct the addition of each complimentary deoxynucleotide. Replicating apparatus: dna replication is complex and is carried out by a multi enzyme complex.
