ADMS 3502 Chapter Notes - Chapter 10.3: Helicobacter Pylori, Peptic Ulcer, Bowel Obstruction
22 May 2020
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What are the predictors of high risk versus low risk. The size of the ulcer, large ulcers tend to have bigger risk. Acquire it early, but find it later on. Higher risk of poverty = higher risk of h pylori. H pylori lives in stomach and association with duodenal ulcer is over 90% and gastric ulcer association is about 70% Reduces the chance to less than 10% per year once you eradicate it. Very rapid growing incidence of resistance to antibiotics in all fields of medicine, specifically with h pylori where we"re using multiple antibiotics. We used to be able to eradicate h pylori up to 90% but now it requires second and third line therapies. Combine low dose asa and coxib it has similar injury to gastric mucosa as nsaid alone. If you take nsaid + asa is even worse. Celebrex is a coxib inhibitor, whereas nsaids are prostaglandin inhibitors.
