BI308 Chapter Notes - Chapter 2: Gaba Transporter, Monoamine Transporter, Venlafaxine
Document Summary
Stahl chapter 2 notes transporters, receptors, and enzymes. Psychotropic drugs: have many mechanisms of action, have specific molecular sites of action, affect neurotransmission, are associated with changes in behaviour, cognition, and emotion, evidence for psychotherapeutic association is variable. Movement and storage: (binding to neurotransmitter prior to transportation across the membrane: release, recapture (reuptake) involve superfamily of 12-transmembrane-region proteins, reuse, storage involve superfamily of 12-transmembrane-region proteins (binding to, protection. Glycine: consists of high-affinity glutamate transporters, also called the solute carrier slc1. Monoamine transporters (slc6 gene family) as targets of psychotropic drugs. Reuptake involves unique presynaptic transporters but the same vesicular transporter in all 3 monoamines. The same vesicular transporter: vmat2 (vesicular monoamine transporter 2) False substrate = presynaptic transporters have high affinity for the other transporters. Other neurotransmitters transporters (slc6 and slc1 gene families) as targets of psychotropic. Several transporters for the ubiquitous inhibitory neurotransmitter gaba, known as.
