BI308 Chapter Notes - Chapter 1: Reuptake, Autoreceptor, Second Messenger System
Document Summary
Ps33oj stahl chapter 1 notes chemical neurotransmission. Anatomical neurotransmission: anatomically-addressed nervous system, neurons + synapses = physical route that carries electrical signals, asymmetric and anterograde, most common neuron connections are axodendritic, axosomatic or axoaxonic. Chemical neurotransmission: chemically-addressed nervous system, how chemical signals are: Top 6 neurotransmitters: serotonin, norepinephrine, dopamine, acetylcholine, glutamate, gaba. Retrograde neurotransmission: post synaptic neuron to pre synaptic neuron, example; endocannabinoids, nitric oxide, and neurotrophic factors. Very few dopamine re-uptake transport pumps in the prefrontal cortex. Different from the striatum, which has many dopamine reuptake transport pumps present. Therefore, in the prefrontal cortex, dopamine is free to spill over and diffuse to neighbouring dopamine receptors to stimulate them even though there is no synapse at these spillover sites: ex of volume neurotransmission = monoamine autoreceptors. At the somatodendritic end of the neuron. Autoreceptors that inhibit the release of neurotransmitter from the axonal end of the neuron. Neurotransmitter leaked from neuron upon its own receptor.
